%0 Journal Article
%T La regulaci¨®n del transportador de colina de alta afinidad dependiente de AMPc/PKA no es mediada por dopamina en neuronas de retina
%A Garay
%A Jos¨¦ L
%A L¨®pez H
%A William J
%A Mosquera F
%A Elis A
%A Subiela H
%A Jos¨¦ D
%A Loureiro D S
%A Nelson E
%J Archivos Venezolanos de Farmacolog¨ªa y Terap¨¦utica
%D 2010
%I Scientific Electronic Library Online
%X the high affinity choline transporter (hacht) activity is considered to be the rate-limiting step in acetylcholine (ach) synthesis in the cholinergic terminal. recent studies show that hacht contains consensus serine and threonine residues for protein kinase a (pka) phosphorylation. using chick retinal neurons evaluated the effects of the second messenger camp on the hacht activity. the increase of the intracellular camp levels through phosphodiesterase inhibition, adenilatecyclase activation or using a phosphodiesterase-resistant camp analog decreased hacht activity between 29 and 69%. moreover, the activation of dopamine d1-type receptors increase the intracellular camp levels and activates pka, however, the treatment with dopamine d1 or d2 receptor antagonists does not induce changes on transporter activity.
%K high affinity choline transporter
%K protein kinase a
%K dopamine.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0798-02642010000400003&lng=en&nrm=iso&tlng=en