%0 Journal Article %T Modificaciones en los marcadores enzim¨¢ticos hep¨¢ticos promovidos por veneno de ejemplares j¨®venes de crotalus DURISSUS CUMANENSIS %A Noriega Alvarado %A Jos¨¦ Rugby %A Mar¨ªn Barico %A Roberth Gabriel %A Mendoza %A Jos¨¦ Antonio %A ¨¢lvarez Y¨¦pez %A Carmen del Rosario %A Mogoll¨®n Saldivia %A Alexander Antonio %A P¨¦rez-Urrieta %A Mirleny del Carmen %A Salas %A Yaritza %J Archivos Venezolanos de Farmacolog¨ªa y Terap¨¦utica %D 2010 %I Scientific Electronic Library Online %X to determinate the effect of the venom of young crotalus durissus cumanensis on levels of alt, ast and ap, balb/c mice were inoculated intraperitoneal with 0,75 mg/kg of purified venom. serum samples were obtained at different post-injection intervals (1, 3, 6, 12, 24h) and serum levels of alt, ast and ap were determined. a significative difference (p £¿0,01) was observed in serum levels of alt at 6h and at 24h post-venom injection, with a maximum of 587,64 u/l at 24 h, when compared with controls. in addition, ast shows a significative elevation between 1h and 12h post venom injection, with a maximum level of 2327 u/l at 3 h, while ap only showed significant differences at 24 h post-venom injection. these results suggest that the venom of young crotalus durissus cumanensis induced liver-biliar injury, with a possible effect on skeletal muscle and/ or cardiac tissue. %K crotalus %K liver injury %K alanin-amino transferase %K aspartate-amino transferase %K alkaline phosphatase. %U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0798-02642010000400004&lng=en&nrm=iso&tlng=en