%0 Journal Article
%T SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES
%A MISHRA
%A RAVINESH
%A KUMAR
%A RAJIV
%A KUMAR
%A SURESH
%A MAJEED
%A JASEELA
%A RASHID
%A MOHD
%A SHARMA
%A SAMEER
%J Journal of the Chilean Chemical Society
%D 2010
%I Scientific Electronic Library Online
%R 10.4067/S0717-97072010000300019
%X some 4-[{1-(substituted)methylidine}-amino]-3-(4-pyridyl)-5-mercapto-4h-1,2,4-triazol (3a- 3f) and n-[5-(4-substituted)-1h-1,2,3-triazol-1-yl] isonicotinamide derivatives (5a- 5e) were synthesized by a sequence of reactions starting from isonicotinic acid hydrazide and is illustrated in scheme 1 and 2. the antibacterial and antifungal activities of newly synthesized compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive staphylococcus aureus and bacillus subtilis, gram negative escherichia coli and the fungi aspergillus niger and candida albicans. ciprofloxacin and fluconazole at 50 ¦Ìg/ml were used as standard drugs for antibacterial and antifungal activities, respectively. all the synthesized compounds showed significant activity against various microorganisms.
%K triazole derivatives
%K antimicrobial activity
%K ciprofloxacin
%K fluconazole.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-97072010000300019&lng=en&nrm=iso&tlng=en