%0 Journal Article
%T New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
%A Lima
%A L¨ªdia M.
%A Ormelli
%A Claudia B.
%A Fraga
%A Carlos A.M.
%A Miranda
%A Ana L.P.
%A Barreiro
%A Eliezer J.
%J Journal of the Brazilian Chemical Society
%D 1999
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50531999000500013
%X as part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). the new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. the anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by adp, collagen, arachidonic acid and u-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-n-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
%K safrole in synthesis
%K phenylsulfonylthiosemicarbazide derivative
%K antithrombotic activity.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50531999000500013&lng=en&nrm=iso&tlng=en