%0 Journal Article %T Trends in multidrug-resistant tuberculosis %A Dias-Baptista %A I. M. F. %A Us¨® %A S. M. R. S. %A Marcondes-Machado %A J. %J Journal of Venomous Animals and Toxins including Tropical Diseases %D 2008 %I Centro de Estudos de Venenos e Animais Pe?onhentos - CEVAP, Universidade Estadual Paulista - UNESP %R 10.1590/S1678-91992007007500001 %X multidrug-resistant tuberculosis (mdr-tb) is an increasing global problem. the extent and burden of mdr-tb varies significantly from country to country and region to region. globally, about three per cent of all newly diagnosed patients have mdr-tb and the proportion is higher in patients who had previously received anti-tuberculosis (anti-tb) treatment reflecting the failure of programs designed to ensure complete cure of patients with tuberculosis. the management of mdr-tb is a challenge that should be undertaken by experienced clinicians at centers equipped with reliable laboratory services and implementation of dots-plus strategy. %K tuberculosis %K mdr-tb %K xdr-tb %K dots %K dots-plus. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-91992008000200003&lng=en&nrm=iso&tlng=en