%0 Journal Article
%T The Drosophila foraging Gene Mediates Adult Plasticity and Gene¨CEnvironment Interactions in Behaviour, Metabolites, and Gene Expression in Response to Food Deprivation
%A Clement F. Kent
%A Tim Daskalchuk
%A Lisa Cook
%A Marla B. Sokolowski
%A Ralph J. Greenspan
%J PLOS Genetics
%D 2009
%I Public Library of Science (PLoS)
%R 10.1371/journal.pgen.1000609
%X Nutrition is known to interact with genotype in human metabolic syndromes, obesity, and diabetes, and also in Drosophila metabolism. Plasticity in metabolic responses, such as changes in body fat or blood sugar in response to changes in dietary alterations, may also be affected by genotype. Here we show that variants of the foraging (for) gene in Drosophila melanogaster affect the response to food deprivation in a large suite of adult phenotypes by measuring gene by environment interactions (GEI) in a suite of food-related traits. for affects body fat, carbohydrates, food-leaving behavior, metabolite, and gene expression levels in response to food deprivation. This results in broad patterns of metabolic, genomic, and behavioral gene by environment interactions (GEI), in part by interaction with the insulin signaling pathway. Our results show that a single gene that varies in nature can have far reaching effects on behavior and metabolism by acting through multiple other genes and pathways.
%U http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000609