%0 Journal Article %T Resolution of Chronic Subdural Hematoma after Treatment with Tumor Necrosis Factor Alpha Inhibitor %A Donald Ross %J Neuroscience & Medicine %P 347-350 %@ 2158-2947 %D 2011 %I Scientific Research Publishing %R 10.4236/nm.2011.24045 %X Background and Importance: Chronic subdural hematomas (cSDH) are a common problem for which solutions remain imperfect. Surgery is effective, but not without risk. Recent data have suggested a role for inflammation in the genesis of cSDH and several reports have documented some benefit to steroid treatment. In this report, a possible role for tumor necrosis factor alpha blockade in the resolution of a multiply recurrent cSDH is described. Clinical Presentation: An 86-year-old man with rheumatoid arthritis treated with infliximab presented with a large, symptomatic, multiloculated cSDH. Infliximab was withheld and craniotomy for evacuation was uncomplicated, but recurrent symptoms were noted and a recurrence was operated upon again several weeks later. Follow up CT showed a second recurrence. The patient requested to go back on his infliximab due to painful arthralgias. After a single dose of 10 mg/kg, follow up CT showed that the cSDH resolved and did not recur. Conclusion: Anti-TNF-alpha treatment with infliximab may have played a role in the resolution of this patient¡¯s cSDH. Further investigation of this possible effect seems warranted. %K Chronic Subdural Hematoma %K Tumor Necrosis Factor Alpha %K Inflammation %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=8882