%0 Journal Article
%T Determination of Camylofin Dihydrochloride and Nimesulide in Pharmaceutical Preparation by Gas Chromatography
%A Rajeev Kumar R. Singh
%A Manapragada V. Rathnam
%A Sangeeta J. Singh
%A Raju V. K. Vegesna
%J American Journal of Analytical Chemistry
%P 944-952
%@ 2156-8278
%D 2011
%I Scientific Research Publishing
%R 10.4236/ajac.2011.28110
%X This research paper describes simple analytical method for determination of Camylofin dihydrochloride and Nimesulide in tablet formulation by Gas chromatography method. Benzoic acid was used as internal standard. Validation was carried out in compliance with the International Conference on Harmonization guidelines. The method utilized GC (Agilent Technologies 6890 N Network GC system with FID detector), and RTX-5 capillary column (5% diphenyl-95% dimethyl polysiloxane), 30 m × 0.53 mm, 1.5 µm as stationary phase. Helium was used as the carrier gas at a flow rate of 1.5 mL?min¨C1. The proposed method was validated for linearity, LOD, LOQ, accuracy, precision, ruggedness and solution stability. It can be conveniently adopted for routine quality control analysis.
%K Capillary Column
%K Gas Chromatography
%K Pharmaceutical Preparations
%K Camylofin Dihydrochloride
%K Nimesulide
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=8986