%0 Journal Article
%T Cytotoxic T Cells in H. pylori-Related Gastric Autoimmunity and Gastric Lymphoma
%A Mathijs P. Bergman
%A Mario M. D'Elios
%J Journal of Biomedicine and Biotechnology
%D 2010
%I Hindawi Publishing Corporation
%R 10.1155/2010/104918
%X Helicobacter pylori infection is the major cause of gastroduodenal pathologies, but only a minority of infected patients develop gastric B-cell lymphoma, gastric autoimmunity, or other life threatening diseases, as gastric cancer or peptic ulcer. The type of host immune response against H. pylori, particularly the cytolytic effector functions of T cells, is crucial for the outcome of the infection. T cells are potentially able to kill a target via different mechanisms, such as perforins or Fas-Fas ligand interaction. In H. pylori-infected patients with gastric autoimmunity cytolytic T cells, that cross-recognize different epitopes of H. pylori proteins and H
%U http://www.hindawi.com/journals/biomed/2010/104918/