%0 Journal Article %T Role of Ryanodine Receptor Subtypes in Initiation and Formation of Calcium Sparks in Arterial Smooth Muscle: Comparison with Striated Muscle %A Kirill Essin %A Maik Gollasch %J Journal of Biomedicine and Biotechnology %D 2009 %I Hindawi Publishing Corporation %R 10.1155/2009/135249 %X Calcium sparks represent local, rapid, and transient calcium release events from a cluster of ryanodine receptors (RyRs) in the sarcoplasmic reticulum. In arterial smooth muscle cells (SMCs), calcium sparks activate calcium-dependent potassium channels causing decrease in the global intracellular [Ca2 %U http://www.hindawi.com/journals/biomed/2009/135249/