%0 Journal Article %T Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives %A Hamdi M Hassaneen %A Huwaida M. E Hassaneen %A Yasmin Sh Mohammed %J Natural Science %P 651-660 %@ 2150-4105 %D 2011 %I Scientific Research Publishing %R 10.4236/ns.2011.38089 %X The reaction of 1-methylisoquinoline 1 with hy-drazonoyl halides 2 in ethanol in the presence of chitosan under microwave irradiation affords triazoloisoquinoline 4. Product 4 reacts with dimethylformamide-dimethylacetal to give ena- minones 7 which react with hydrazonoyl halides to give pyrazolyl triazoloisoquinoline 13. Also, 1-methylisoquinoline 1 reacts with arylisothio-cyanate to give thioanilide 15 which reacts with hydrazonoyl halides to give the corresponding thiadiazolyl isoquinoline derivatives 20, 24. %K [1 %K 2 %K 4]Triazolo[3 %K 4-a]isoquinolines %K Enaminones %K Hydrazonoyl Halides %K Cycloaddition Reactions %K Chitosan %K Thioanilides %K [1 %K 3 %K 4]Thiadiazolylisoquinoline Derivatives %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=6590