%0 Journal Article
%T The Impact of Neutrophil to Lymphocytic Ratio (NLR) as a Predictor of Treatment Outcomes in Rectal Carcinomas: A Retrospective Cohort Study
%A Samir Eid
%A Hoda Hasan
%A Doaa Abdel-Aleem
%A Amal Rayan
%J Journal of Cancer Therapy
%P 755-777
%@ 2151-1942
%D 2019
%I Scientific Research Publishing
%R 10.4236/jct.2019.109064
%X <strong>Background and aim</strong><span style=\"\" capt?,serif;?=\"\" pro=\"\" minion=\"\"><span style=\"font-family:Verdana;\"><strong>:</strong> The prognostic role of neutrophil to lymphocyte ratio (NLR) has been shown in many solid tumors included in a recent meta-analysis of one hundred studies. We aimed to evaluate the prognostic value of neutrophil to lymphocyte ratio in treatment outcomes; response and survival of patients with different stages of rectal cancers. </span><b><span style=\"font-family:Verdana;\">Patients and methods</span></b><span style=\"font-family:Verdana;\">: All patients with pathologically confirmed cancer rectum presented to our department during the period from January 2012 to the end of 2014 were included in this retrospective study, these recruited patients were evaluated through their files to determine different objectives of our study</span></span><span style=\"font-family: Verdana;\" capt?,serif;?=\"\" pro=\"\" minion=\"\">.</span><span style=\"\" capt?,serif;?=\"\" pro=\"\" minion=\"\"> <b><span style=\"font-family:Verdana;\">Results</span></b><span style=\"font-family:Verdana;\">: The median overall survival was 31 ¡À 4.676 months while </span><span style=\"font-family:Verdana;\">disease free</span><span style=\"font-family:verdana;\"><span style=\"font-family:Verdana;\"> survival was 40 ¡À 2.346 for the whole study group; neutrophil to lymphocyte ratio was negatively correlated with overall survival with r = </span><span style=\"font-family: Verdana;\" roman?,serif;?=\"\" new=\"\" times=\"\">¨C</span><span style=\"font-family:Verdana;\">0.743</span></span></span><span style=\"font-family: Verdana;\" capt?,serif;?=\"\" pro=\"\" minion=\"\">,</span><span style=\"\" capt?,serif;?=\"\" pro=\"\" minion=\"\"><span style=\"font-family:Verdana;\"> P &lt; 0.001, also with </span><span style=\"font-family:Verdana;\">disease free</span><span style=\"font-family:verdana;\"><span style=\"font-family:Verdana;\"> survival with r = </span><span style=\"font-family: Verdana;\" roman?,serif;?=\"\" new=\"\" times=\"\">¨C</span><span style=\"font-family:Verdana;\">0.717, P &lt; 0.0001. Neutrophil to lymphocyte ratio was positively correlated with the number of positive lymph nodes dissected to </span></span><span style=\"font-family:Verdana;\">total</span><span style=\"font-family:Verdana;\"> number of lymph nodes dissected ratio with r = +0.254, P</span></span><span style=\"font-family: Verdana;\" capt?,serif;?=\"\" pro=\"\" minion=\"\"> = </span><span style=\"\" capt?,serif;?=\"\" pro=\"\" minion=\"\"><span
%K Neutrophil to Lymphocyte Ratio
%K Overall Survival
%K Disease Free Survival
%K Rectal Carcinomas
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=95241