%0 Journal Article
%T Influence of DAP1 Genotype and Psychosocial Factors on Posttraumatic Stress Disorder in Thai Tsunami Survivors: A GxE Approach
%A Nuntika Thavichachart
%A Prathan Rutchatajumroon
%A Taisei Mushiroda
%A Anchalee Prasansuklab
%A Sookjaroen Tangwongchai
%A Puangsoi Worakul
%A Buranee Kanchanatawan
%A Siriluck Suppapitiporn
%A Atapol Sughondhabirom
%A Chutima Roomruangwong
%A Ongart Charoensook
%A Wasun Chantratita
%A Atsushi Takahashi
%A Michiaki Kubo
%A Naoyuki Kamatani
%A Yusuke Nakamura
%J Open Journal of Genetics
%P 65-75
%@ 2162-4461
%D 2019
%I Scientific Research Publishing
%R 10.4236/ojgen.2019.93005
%X <strong>Background:</strong> Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder found in individuals afflicted by a traumatic event including the natural disaster. ˇ°Tsunamiˇ± occurred in Andaman coast of Thailand on December 26, 2004, in which 33.6% of survivors were diagnosed as PTSD. This study aimed to explore the single nucleotide polymorphism (SNP). rs267943 genotype is located on chromosome 5 in the intron of the death-associated protein 1 (DAP1) gene and psychosocial factors for PTSD. <strong>Methods:</strong> Participants (N = 1970) were recruited from volunteers who have complete data both of DAP1 gene and psychosocial factor. <strong>Results:</strong> Using a binary logistic regression model, significant gene-environment interactions were found for the single nucleotide polymorphism (SNP) rs267943 and psychosocial factors including depression (adj. OR = 6.0, 95% CI = 4.29 - 8.39), neurotic personality (adj. OR = 2.73, 95% CI = 2.18 - 3.42), planning (adj. OR = 1.52, 95% CI = 1.20 - 1.93), use of emotional support (adj. OR = 1.32, 95% CI = 1.21 - 1.94) with statistical significant p &lt; 0.001 and self-distraction (adj. OR = 1.52, 95% CI = 1.15 - 1.85) with statistical significant p &lt; 0.05. <strong>Conclusion:</strong> This study demonstrated that GxE studies can be utilized to shed light on the origins of PTSD.
%K Death-Associated Protein 1 Gene (DAP1)
%K Gene-by-Environment Interaction (GxE)
%K Genetype
%K Posttraumatic Stress Disorder (PTSD)
%K Psychosocial Factors
%K Tsunami
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=94840