%0 Journal Article
%T Clinical and Pathological Value of MACC-1 Expression in Gastric Carcinoma
%A Abeer Hafez
%A Tarek El-Gohary
%A Fouad Abutaleb
%J Journal of Cancer Therapy
%P 609-618
%@ 2151-1942
%D 2019
%I Scientific Research Publishing
%R 10.4236/jct.2019.107050
%X <strong>Background:</strong><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">Gastric adenocarcinoma is known to be a markedly
invasive</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">disease</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> with
high potential for</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">metastasis. Hepatocyte growth factor (HGF)/HGF receptor (MET) signaling
pathway activation is an assumed mechanism of malignant transformation and
metastatic potential of tumors. Metastasis</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span><span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">associated
with colon cancer-1 (MACC-1) has been identified as a key regulator of </span><a name=\"_Hlk2902471\"></a><span style=\"font-family:Verdana;\">HGF/MET signaling.</span></span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">However,
its role in gastric cancer is not well understood.</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><b><span style=\"font-family:Verdana;\">Aim of
this study</span></b></span></span><span><span><b><span style=\"font-family:;\" \"=\"\"> </span></b></span></span><span><span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">is to assess the expression of MACC-1 in gastric cancer, its relation to
other clinical and pathologic parameters and its impact on progression free and
overall survival. </span><b><span style=\"font-family:Verdana;\">Patient and
Methods:</span></b></span></span></span><span><span><b><span style=\"font-family:;\" \"=\"\"> </span></b></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">Evaluation of MACC-1 protein expression by immune-histochemistry
%K Gastric Cancer
%K MACC-1
%K HGF/MET Signaling
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=93946