%0 Journal Article
%T The Prognostic Value of Vitamin D Insufficiency & Vitamin D Receptor Gene Polymorphism in Adult Acute Myeloid Leukemia Patients
%A Amal Zidan
%A Alaa Omran
%A Rania Ghonaim
%A Fouad Abu-Taleb
%A Tarek Elgohary
%J Journal of Cancer Therapy
%P 361-370
%@ 2151-1942
%D 2019
%I Scientific Research Publishing
%R 10.4236/jct.2019.105030
%X <strong>Background:</strong><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> Vitamin D regulates many aspects of cellular growth and differentiation
in normal and cancer cells. There is growing evidence for both serum vitamin D
level and VDR gene polymorphism as prognostic factors in hematologic
malignancies. </span><b><span style=\"font-family:Verdana;\">Aim of this work:</span></b><span style=\"font-family:Verdana;\"> Evaluation of vitamin D serum level and
VDR FOKI polymorphism as prognostic factors in adult AML patients</span></span><span style=\"font-family:Verdana;\">. </span><b><span style=\"font-family:Verdana;\">Patients &amp; Methods:</span></b><span style=\"font-family:Verdana;\"> Eighty
subjects were included in this study, 50 adult patients with newly diagnosed AML
and 30 apparently healthy controls matched for age and sex. Venous blood
samples were withdrawn from all subjects for measurement of serum 25(OH)
vitamin D</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">using competitive photo chemiluminescence and m</span><span style=\"font-family:Verdana;\">olecular detection of VDR (FOKI) polymorphism</span><span style=\"font-family:Verdana;\">, which</span><span style=\"font-family:Verdana;\"> w</span><span style=\"font-family:Verdana;\">as</span><span style=\"font-family:Verdana;\"> done by</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">RFLP PCR. All patients received the standard
induction chemotherapy regimen 3</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">&amp;</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">7.</span><span style=\"font-family:;\" \"=\"\"> </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">The rate of</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">vitamin
D insufficiency was significantly higher in AML patients compared to controls
(58% vs 16%, p = 0.03). The mutant FOKI genotype (FF &amp; Ff) was found in 52
% of patients compared to 23 % of controls (p = 0.02). Patient with sufficient
vitamin D level showed a significantly higher complete response rate compared
to those with insufficient level (90% vs 44%, p = 0.02), while none of the
other clinical features showed significant relation. Patients with wild type
FOKI polymorphism (FF) were more likely to have favorable cytogenetics, while
patient with mutant FOKI polymorphism</span><span
%K Vitamin D
%K VDR
%K FOKI
%K Polymorphism
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=92472