%0 Journal Article
%T Sequential and Dual Inhibition of Pleiotropic Targets in Cancer¡ªA Novel Strategy to Sensitize Tumor Cells to Targeted Therapies and Overcome Resistance
%A M. Nezami
%J Journal of Cancer Therapy
%P 166-177
%@ 2151-1942
%D 2019
%I Scientific Research Publishing
%R 10.4236/jct.2019.102013
%X In this paper we discuss the rationale of applying a ¡°sequential¡±
targeted therapy with a specific application in clinical practice, given our
understanding of cancer heterogenous and dynamic biology. We explore the
advantages of ¡°single inhibition¡± to combinational therapies and dual
inhibition on key pathways, as well as a multi-step approach to use
¡°oncological addiction¡± and ¡°oncogenic shock¡± as a suicide plan for cancer. We specifically
explain how the downstream targets can be used to ¡°create¡± feedback loops in an
advantage for creating actionable targets in upstream signaling molecules. We
apply this hypothesis in the clinical setting, with superior outcomes shown in
a series of case studies. We conclude that ¡°sequential and dual inhibition¡± can
be considered a meaningful approach to checkmate the tumor, with <span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">minimum chance</span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> of tumor resistance. We recommend further clinical studies to generate
further hypotheses based on each actionable target.</span></span></span>
%K Targeted Therapies
%K Multitargeted Epigenetic Therapy
%K Oncogenic Addiction
%K Tumor Resistance
%K Tyrosine Kinase
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=90650