%0 Journal Article
%T Impact of HIV Status, CD4 Count and Antiretroviral Treatment on Tuberculosis Treatment Outcomes in a Low-Burden Country
%A Vera Cl¨¦rigo
%A Teresa Mourato
%A Concei£¿£¿o Gomes
%A Ana Castro
%J Journal of Tuberculosis Research
%P 281-291
%@ 2329-8448
%D 2018
%I Scientific Research Publishing
%R 10.4236/jtr.2018.64025
%X <strong>Background:</strong> Few data is available in low-burden TB-HIV countries on TB treatment outcomes. We evaluated TB patients (pts) characteristics by HIV status and compared treatment outcomes in relation to HIV status, CD4 count and antiretroviral therapy (ART). <strong>Methods:</strong> We performed a retrospective analysis of 447 adult TB pts who registered and initiated treatment in our center from 2014 to 2015. <strong>Results:</strong> Pts were categorized as HIV-negative (n = 399, 89.3%), HIV-positive on ART (n = 42, 9.4%) and HIV-positive not on ART (n = 6, 1.3%). The proportion of pts with extended TB therapy was higher among HIV-positive pts (p = 0.03). Increased age was associated with higher death rates regarding treatment success (OR 1.08; 95% CI 1.01 - 1.17, p = 0.03). Statistically significant higher mortality was found among HIV-positive pts on ART (OR 9.93; 95% CI 1.36 - 72.37, p = 0.03) and HIV-positive pts not on ART (OR 397.00; 95% CI 44.27 to 3559.91, p ¡Ü 0.0001) compared to HIV-negative pts. When multivariate analyses were restricted to HIV-positive pts, being not on ART was associated with higher mortality (OR 40.0; 95% CI 4.37 - 365.78, p = 0.001). <strong>Conclusions:</strong> There was significant difference in death rates between HIV-positive and HIV-negative TB pts. HIV-positive pts not on ART had a significantly higher mortality.
%K Tuberculosis Treatment Outcomes
%K HIV Infection
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=88479