%0 Journal Article
%T Evaluation of the Liver Cancer Prevention of Anthocyanin Extracts from Mulberry (<i>Morus alba</i> L.) Variety PR-01
%A Sufeng Liao
%A Jianghong Liu
%A Ming Xu
%A Jingui Zheng
%J Advances in Bioscience and Biotechnology
%P 423-442
%@ 2156-8502
%D 2018
%I Scientific Research Publishing
%R 10.4236/abb.2018.99030
%X This study aims to evaluate the preventive effects
of anthocyanins extracts <span><span style=\"font-family:Verdana;\">(MAEs) from mulberry
variety PR-01 against </span><i><span style=\"font-family:Verdana;\">N</span></i><span style=\"font-family:Verdana;\">-nitrosodiethylamine </span></span><span style=\"font-family:Verdana;\">(NDEA)-induced hepatocarcinogenesis in rats. It was found that 150 mg¡¤kg</span><sup><span style=\"font-family:Verdana;\">-</span></sup><sup><span style=\"font-family:Verdana;\">1</span></sup><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> MAEs treatment significantly reduced the NDEA-induced
hepatic nodules incidence and hepatocellular carcinoma incidence by 58.30% and
41.70% compared to the model group. Meanwhile, MAEs significantly restored the
elevated the liver function enzymes, inhibited the tumor necrosis factor alpha
and interleukin-6 levels, elevated the serum interleukin-10 and interferon-</span><i><span style=\"font-family:Verdana;\">¦Ã</span></i> <span style=\"font-family:Verdana;\">and
increased hepatic glutathione-S-transferase and UDP-glucuronosyltransferase</span><span style=\"font-family:Verdana;\"> 2B1 enzyme activity. Moreover, 150 mg¡¤kg</span></span><sup><span style=\"font-family:Verdana;\">-</span></sup><sup><span style=\"font-family:Verdana;\">1</span></sup><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\"> MAEs supplement enhanced glutathione content and
the activities of superoxide dismutase, catalase, glutathione peroxidase
activities but reduced the malondialdehyde and thiobarbituric acid-reactive
substances content by 37.90% and 44.52%. Furthermore, MAEs pretreatment maintained
nuclear factor erythroid 2-related factor 2 </span><span style=\"font-family:Verdana;\">(Nrf2),
Kelch-like ECH-associated protein 1, heme oxygenase-1, and NAD(P)H:</span><span style=\"font-family:Verdana;\"> quinine
oxidoreductase1 stimulation and inhibited the expression of TNF-</span><i><span style=\"font-family:Verdana;\">¦Á</span></i><span style=\"font-family:Verdana;\">, nuclear factor-kappaB (NF-</span><i><span style=\"font-family:Verdana;\">¦Ê</span></i><span style=\"font-family:Verdana;\">B), and cyclooxygenase-2 (COX-2), indicating
that MAEs exhibit effectively prevention effects against liver cancer via
decreased lipid peroxidation, induced Nrf2-mediated antioxidant enzymes and
attenuating the inflammatory mediators COX-2 through NF-</span><i><span style=\"font-family:Verdana;\">¦Ê</span></i><span style=\"font-family:Verdana;\">B pathway. Thus, MAEs of mulberry variety
%K Mulberry (&lt
%K i&gt
%K Morus alba&lt
%K /i&gt
%K L.) Anthocyanins Extracts
%K N-Nitrosodiethylamine
%K Hepatocarcinogenesis
%K Antioxidation
%K Anti-Inflammatory
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87348