%0 Journal Article
%T Prediction of the Fragmentation Pathway of Valsartan Protonated Ion
%A Dev Kant Shandilya
%A Rekha Israni
%A Peter Edward Joseph
%J Open Access Library Journal
%V 5
%N 9
%P 1-15
%@ 2333-9721
%D 2018
%I Open Access Library
%R 10.4236/oalib.1104764
%X <div style="text-align:justify;">
	<span style="line-height:1.5;">Introduction: A fragmentation pathway of valsartan protonated ion proposed based on rational interpretation workflows. Method: The mass spectral data (MS, MS/MS, and MS3) of valsartan protonated ion, were attained by electrospray positive ionization with flow injection analysis; using liquid chromatography systems hyphenated with hybrid tandem mass spectrometer (Q-trap). Results: The pathway of fragm</span><span style="line-height:1.5;">entation was established using product ions of the protonated ion; elemental composition, molecular structure and mechanism of formation for significant product ions were proposed. A pathway was proposed based on the MS/MS and MS3 spectral data in combination with basic interpretation rules and rational workflows. Conclusion: Workflow used for data interpretation can be useful for writing the fragmentation pathway, a mechanism for the formation of fragments, and can be applied for mass spectral data interpretation of similar small organic molecules.</span>
</div>
%K Valsartan
%K Small Organic Molecules
%K Fragmentation Pathway
%K Protonated Ion
%K Fragmentation
%K Interpretation
%U http://www.oalib.com/paper/5298294