%0 Journal Article
%T Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities¡ªMetabiotics: Probiotics Effector Molecules
%A Aarti Singh
%A Vishakha Vishwakarma
%A Barkha Singhal
%J Advances in Bioscience and Biotechnology
%P 147-189
%@ 2156-8502
%D 2018
%I Scientific Research Publishing
%R 10.4236/abb.2018.94012
%X The
intricate ¡°orchestered molecular conversation¡± between the host and gut
microbiome is one of the most dynamic research areas in recent years. The
rhythmic chemical cross talk in the form of bioactive metabolites and
signalling molecules synthesized by gut microbiome plays <span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">a </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">significant role for the
modulation of human health in diversified ways. They are recognized as low
molecular weight (LMW) molecules having versatile chemical attributes. They
possess magnificent capability of interacting with surrounding environment and
controlling the genes for various genetic, biochemical and physiological
functions for maintaining the homeostasis that is now-a-days termed as ¡°small
molecules microbes originated (SMOM) homeostasis¡± in the host. These metabolic
signatures have close structural and functional resemblance with small
molecules synthesized by host eukaryotic cells and dietary components. Therefore,
they may be considered as universalized metabolites contributing to the
remarkable phenomenon of epigenetic regulation, cell to cell communication and
stability of genome manifesting the overall growth and development of the host
and known as ¡°metabiotics¡±. The wide panorama of utilization of probiotics is
continuously expanding and conferring the major health benefits through metabiotic
components are gaining tremendous momentum therefore recognized as ¡°hidden
soldiers¡± of the body. Therefore firstly, we outline the need and types of
metabiotic molecules and depicting their role in human health. Then, we
summarize their preventive and therapeutic avenues in various diseases and finally,
we propose the current technological interventions, bottlenecks and future
perspectives in this field that are implied for accelerating their
comprehensive understanding and utilization at industrial scale.</span></span></span>
%K Metabiotics
%K Probiotics
%K Metabolic Signatures
%K Gut Microbiome
%K Homeostasis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=84149