%0 Journal Article
%T Localizing the Language Network with fMRI and Functional Connectivity: Implications for Pre-Surgical Planning
%A Victoria Lyn Ives-Deliperi
%A James Thomas Butler
%J Open Journal of Modern Neurosurgery
%P 174-186
%@ 2163-0585
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojmn.2018.82015
%X <p style=\"text-align:justify;\">
	<b><span style=\"font-family:Verdana;\">Object</span></b><span style=\"font-family:Verdana;\">: Functional
MRI is frequently applied to lateralize</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">language
in pre-surgical planning, with potential</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">to localize
functionally important cortex too.</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">Here we present BOLD signal activation
maps and related functional connectivity, in response to three commonly administered
fMRI language tasks. </span><b><span style=\"font-family:Verdana;\">Methods</span></b><span style=\"font-family:Verdana;\">: Datasets from 55 pre-surgical fMRI studies
were analyzed. Verbal response naming, covert word generation and passive listening
tasks were administered in all studies. Single-subject analyses, group analyses
and region-of-interest analyses were conducted, and a multi-subject functional connectivity
analysis was performed. </span><b><span style=\"font-family:Verdana;\">Results</span></b><span style=\"font-family:Verdana;\">: Single-subject analyses revealed that</span></span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">clinically</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">important</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">language regions were activated
in all but three patients using the panel of tasks. Group analyses revealed</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">significant bilateral BOLD signal increases in</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">anterior
and posterior</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">language regions</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">in response
to verbal response naming and bilateral signal increase in posterior language regions
only in response to passive listening. Covert word generation</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">activated anterior language regions bilaterally and posterior language cortex</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">in the dominant hemisphere. Functional
%K Brain Mapping
%K fMRI
%K Functional Connectivity
%K Language
%K Pre-Surgical Planning
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=83665