%0 Journal Article
%T Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs
%A Mar¨ªa L. Arias
%A Eugenia Corrales
%A Rebeca Poveda
%A Jorge A. Cabezas
%J International Journal of Organic Chemistry
%P 115-124
%@ 2161-4695
%D 2018
%I Scientific Research Publishing
%R 10.4236/ijoc.2018.81007
%X Natural product jacaranone, <b>1</b>, and three
analog derivatives were synthesized and their apoptotic and necrotic activity
against four cancer cell lines was tested. One of these derivatives <b>7</b>,
was more active than the natural product, and exhibited an important necrotic
effect against three of the cell lines tested (ovarian carcinoma, liver cancer
and breast cancer cells). Derivative <b>6</b> was more active than the natural
product, and showed a significant apoptotic activity against breast cancer and
ovarian carcinoma cells. Some derivatives analyzed in this study showed
promising anti-tumor results, nevertheless, further studies have to be done in
order to determine their <i>in vivo</i> activity, their mechanism as well as their safety and stability.
%K Jacaranone
%K Jacaranone Synthetic Analogs
%K Antitumor Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=82845