%0 Journal Article
%T Synthetic Approach for Novel Fluorine Substituted <i>¦Á</i>-Aminophosphonic Acids Containing 1,2,4-Triazin-5-One Moiety as Antioxidant Agents
%A Mohammed S. T. Makki
%A Reda M. Abdel-Rahman
%A Abdulrahman S. Alharbi
%J International Journal of Organic Chemistry
%P 1-15
%@ 2161-4695
%D 2018
%I Scientific Research Publishing
%R 10.4236/ijoc.2018.81001
%X Novel fluorine substituted ¦Á-amino
phosphonic acids containing 1,2,4-triazin- 5-one (6a-f) have been obtained from
fluoroacylation of 6-(2′-amino-5′-nitrophenyl)-3-thioxo-1,2,4-triazin-5(4H)-one
(1) followed by ammonilysis to give the corresponding 3-amino-derivative 3. Condensation of compound 3 with nitro/halogenated aromatic
aldehydes yielded the Schiff bases 4. The simple addition of diethyl
phosphonate to compound 4 produced the ¦Á-amino phosphonates 5.
Acidic hydrolysis of compound 5 produced the
fluorine substituted ¦Á-amino acids derivatives 6. Structures of the new compounds have
been established with the help of elemental analysis and spectral measurements.
Also, the products evaluated as antioxidants, where the fluorinated ¦Á-amino phosphonic acids 6 are more active than the other synthesized systems.
%K Synthetic
%K Fluorine ¦Á-Amino Acids
%K 1
%K 2
%K 4-Triazin-5-One Moiety
%K Antioxidants Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=81770