%0 Journal Article
%T Renal Disease among HIV Positive Patients in Senegal
%A Khodia Fall
%A Mouhamadou Moustapha Ciss¨¦
%A Ahmed Tall Lemrabott
%A Maria Faye
%A Mouhamed Cherif Dial
%A Atoumane Faye
%A Seynabou Fall
%A Moustapha Faye
%A Alex Keita
%A Mansour Mbengue
%A Seynabou Diagne
%A Niakhaleen Keita
%A Bacary Ba
%A Abdou Niang
%A Boucar Diouf
%A El Hadji Fary Ka
%J Open Journal of Nephrology
%P 101-106
%@ 2164-2869
%D 2017
%I Scientific Research Publishing
%R 10.4236/ojneph.2017.74012
%X <strong>Introduction:</strong> Renal disease (RD) in human immunodeficiency virus (HIV) infection is a decisive turning point in the development and prognosis of this disease. In Africa, the prevalence varies between 2.5% and 48.6%. In Senegal, little data are available in the literature. The objective of our study was to describe the epidemiological, clinical, paraclinical, therapeutic and progressional aspects in patients living with HIV (PLWHIV). <strong>Patients and methods:</strong> This was a retrospective, descriptive and analytical study carried out over a 10-year period in the Department of Internal Medicine and Nephrology at the Aristide Le Dantec Hospital in Dakar, Senegal. We included all 15-year old and above PLHIV with available CD4 count and viral load. <strong>Results:</strong> Out of 248 PLHIV, 32 had kidney disease (KD), which means a hospital prevalence of 12.9%. The mean age was 51.22 ¡À 10 years (extremes of 36 and 77 years) with a sex ratio (male/female) of 1.28. Renal signs were dominated by glomerular nephropathy syndrome. It was present at 80%. Tubulo-interstitial nephropathy syndrome and chronic uremic syndrome accounted for 6.25% and 3.1% of cases, respectively. Renal function Impairment was present in 21 patients with 18 cases of acute kidney injury (85.7%) and 3 cases of chronic renal failure (14.3%), including 2 in stage 5 of chronic kidney disease. Renal biopsy (RB) was indicated and performed in 20 (62.5%) patients with glomerular signs in 12 patients (60%). Glomerular lesions were dominated by focal and segmental glomerulosclerosis (FSGS) in 6 cases, membraneous nephropathy (MN) in 4 cases and minimal change disease (MCD) in 2 cases. Tubulo-interstitial and vascular lesions were present in 45% and 12.5% of cases, respectively. In highly active antiretroviral therapy (HAART), 12 (37.5%) patients had total remission, 9 (28.12%) had partial remission. One (3.12%) death from severe metabolic acidosis on chronic renal failure was deplored. <strong>Conclusion:</strong> This study illustrates the high prevalence of RD in PLHIV in our exercise context.
%K Kidney Disease
%K HIV
%K HIVAN
%K Senegal
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=81525