%0 Journal Article
%T The Synergistic Effects Study of C-myc and C-erbB-2 in the Carcinogenesis of Gastric Carcinoma
%A Keqiang Wang
%A Jiangang Liu
%A Yanchao Duan
%A Shengyi Dongye
%A Jiafeng Wu
%A Yiren Wang
%A Zhenzhong Liu
%A Guoxin Han
%J Open Journal of Gastroenterology
%P 308-315
%@ 2163-9469
%D 2017
%I Scientific Research Publishing
%R 10.4236/ojgas.2017.712032
%X Objective: To study the significance of c-myc and c-erbB-2 oncogene expression in gastric cancer. Methods: 81 gastric cancer specimens were detected for c-myc and c-erbB-2 oncogene amplification using non-radioactive in situ hybridization method. Results: The amplification rates for c-myc and c-erbB-2 were 67.9% and 50.6% respectively, and there were significant correlation in the amplification of these two genes (¦Ö2 = 7.26, P < 0.01). Conclusions: The amplification of c-myc and c-erbB-2 may play an important role in gastric cancer development, and these two genes may have synergistic effect.
%K c-myc
%K c-erbB-2
%K Synergistic Effects
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=81380