%0 Journal Article
%T Cytotoxicity Study of Gold Nanoparticles on the Basal-Like Triple-Negative HCC-1937 Breast Cancer Cell Line
%A Christophe Massard
%A Cl¨¦mence Dubois
%A Vincent Raspal
%A Pierre Daumar
%A Yves Sibaud
%A Emmanuelle Mounetou
%A Mahchid Bamdad
%A Oscar Komla Awitor
%J Journal of Biomaterials and Nanobiotechnology
%P 13-25
%@ 2158-7043
%D 2018
%I Scientific Research Publishing
%R 10.4236/jbnb.2018.91002
%X The Triple Negative ˇ°Basal-likeˇ±
breast cancer (TNBL) tumours have a high </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">proliferative
capacity and develop a resistance phenotype associated with</span><span style=\"font-family:Verdana;\"> me</span><span style=\"font-family:Verdana;\">tastases. However, the management of TNBL
carcinomas is still not stan</span><span><span style=\"font-family:Verdana;\">dardized. Among
the promising trails, gold nanoparticles could be a relevant tool for the
development of a targeted treatment for this breast cancer subtype in
monotherapy, associated and/or conjugated with other drugs. In this work, we
report the cytotoxicity impact of gold nanoparticles wrapped in Poly-Ethylene
Glycol (PEG) on the TNBL HCC-1937 breast cancer cell line</span><i><span style=\"font-family:Verdana;\">. </span></i></span><span style=\"font-family:Verdana;\">PEG-coated gold nanoparticles (PEG-Au NPs) were
synthesized by a two-step</span><span> </span><span style=\"font-family:Verdana;\">method using
a reduction process followed by a post</span></span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">functionalization</span><span style=\"font-family:Verdana;\"> called </span><span style=\"font-family:Verdana;\">PEGylation.
PEG-Au NPs were characterized using transmission electron</span><span style=\"font-family:Verdana;\"> mi</span><span style=\"font-family:Verdana;\">croscopy
and X-ray diffraction. The gold content of the samples was deter</span><span style=\"font-family:Verdana;\">mined
using atomic absorption spectrometer. The cytotoxicity tests wer</span><span style=\"font-family:Verdana;\">e performed using Sulforhodamine B survival test
and resazurin viability test. PEG-Au NPs impact analysis on HCC1937 TNBL cell
line showed a clear toxic action of type dose dependent and at long term. These
PEGylated gold nanoparticles present a promising tool for the development of
tumor-specific radi</span><span style=\"font-family:Verdana;\">osensitizing vectors, with or without the association
of other treatment</span><span style=\"font-family:Verdana;\"> strategies.
%K Breast Cancer
%K ˇ°Basal-Likeˇ± Triple Negative
%K HCC-1937
%K Gold Nanoparticles
%K Cytotoxicity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=81130