%0 Journal Article %T Interaction of Iron(III)-5,10,15,20-Tetrakis (4-Sulfonatophenyl) Porphyrin with Chloroquine, Quinine and Quinidine %A Dikima D. Bibelayi %A Pitchouna I. Kilunga %A Albert S. Lundemba %A Matthieu K. Bokolo %A Pius T. Mpiana %A Philippe V. Tsalu %A Juliette Pradon %A Colin C. Groom %A Celine W. Kadima %A Luc Van Meervelt %A Zephyrin G. Yav %J Crystal Structure Theory and Applications %P 25-38 %@ 2169-2505 %D 2017 %I Scientific Research Publishing %R 10.4236/csta.2017.63003 %X Iron(III)-5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin (FeTPPS) is used as non-physiological metalloporphyrin model for the natural iron (III)-protoporphyrin IX (FePPIX) resulting from hemoglobin degradation to investigate ligand binding reactions in aqueous solution. Studies were conducted on the interaction of FeTPPS with Chloroquine, Quinine, and Quinidine, which are historically the most common quinoline-based drugs used to treat malaria, an infectious disease afflicting several hundred millions every year worldwide, mainly in tropical regions. Using UV-Visible spectrophotometry, the binding reaction was studied at pH 7.40 in purely aqueous solution, and in aqueous solution containing NaNO3 at concentration of 0.1 M. Fitted titration curves obtained were in agreement with experimental data according to a formation scheme of 1:1 complex (1 FeTPPS ¦Ì-oxo-dimer: 1 Antimalarial). Values of apparent binding constant (K) obtained were between 4.3 ¡Á 103 M-1 to 7.59 ¡Á 104 M-1, demonstrating that FeTPPS and the antimalarials formed stable complexes. The stability of the complex decreased when NaNO3 was added to the solution. This ionic strength dependence was ascribed to electrostatic effects. %K FeTPPS %K Apparent Binding Constant (K) %K Molecular Electrostatic Potential (MEP) %K Cambridge Structural Database (CSD) %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=78372