Aim: To describe the epidemiological, clinical, microbiological and therapeutic features of corneal abscesses related to Contact Lens (CL) wear. Patients and Methods: Retrospective review of 29 patients (29 eyes) with infectious keratitis associated with contact lens wearing was conducted at Ophthalmology Department Fattouma Bourguiba University Hospital of Monastir, Tunisia between January 2006 and June 2016. All patients underwent detailed ophthalmological examination. Slit lamp examination and corneal culture were performed on all patients. The Contact Lens and Contact Lens cases were also analyzed if available. The mean follow-up period was 88 days (range: 30-360 days). Results: The mean age of our patients was 27 year old. Twenty-three patients (97.3%) were females and 6 patients (20.7%) were males. Twenty-seven patients (93.1%) were soft contact lens users. The mean initial Visual Acuity (VA) was 20/1000. Stromal infiltrates were associated with ulcers in all cases, and were located in central cornea in 21 cases (72.4%). Hypopyon was noted in 10 cases (34.5%). Microbial cultures were positive in 18 patients (72.4%). Pseudomonas aeruginosa was isolated in 41.4% of cases. Amoebic cysts were found in 5 cases (17.3%). Fusarium was isolated in one eye (3.5%). Antimicrobial treatment was based on the suspected or isolated causative agent. Final VA was 20/125. Conclusion: Corneal abscesses are a rare but serious complication of CL wear. Educating CL users, early diagnosis and appropriate management are important elements so as to reduce ocular morbidity.