%0 Journal Article
%T The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities
%A Faten I. Hamed
%A Abeer A. Mohamed
%A Amr S. Abouzied
%J Open Access Library Journal
%V 4
%N 5
%P 1-14
%@ 2333-9721
%D 2017
%I Open Access Library
%R 10.4236/oalib.1103526
%X <div style="text-align:justify;">
	<span style="line-height:1.5;">The thiazole derivative 3
was used for a series of heterocyclization reaction to produce pyran, pyridine
and thiazole derivatives. The cytotoxicity of the newly synthesized compounds
was studied against the six cancer cell lin</span><span style="line-height:1.5;">es namely NUGC, HR, DLD1, HA22T, HEPG2, MCF, HONE1 and
normal fibroblast cells (WI38). The results showed that most of the synthesized
compounds were of high potency. Among the tested compounds, 2-Amino-4-(4-chlorophenyl)-6-(4-phenylthiazol-2-yl)-4H-pyran-3,5-dicarbonitrile 17b showed the highest
potency among the tested compounds.</span> 
</div>
%K Thiazole
%K Pyran
%K Pyridine
%K Antitumor
%U http://www.oalib.com/paper/5284873