%0 Journal Article
%T The Impact of Ethnicity on the Incidence, Tumor Characteristics and Treatment of Ductal Carcinoma <i>in Situ</i>¡ªAn 11-Year Clinical Experience at a High Volume Teaching Hospital
%A Lauren S. Sparber
%A Vijayashree Murthy
%A Ronald S. Chamberlain
%J Surgical Science
%P 348-356
%@ 2157-9415
%D 2016
%I Scientific Research Publishing
%R 10.4236/ss.2016.78050
%X Introduction: Screening mammography has led to a marked increase in
detection of in situ breast tumors in the United States. The University of
Southern California/Van Nuys Prognostic Index (USC/VNPI) predicts the
recurrence rates of ductal carcinoma in situ (DCIS); however variations in tumor
characteristics, USC/VNPI scores, receptor and human epithelial growth factor
receptor (HER)-2/neu status across different
ethnicities/races have not been well studied. This study aimed to evaluate the racial trends in incidence,
patient demographics, tumor characteristics and treatment variations for patients with DCIS at a high volume teaching
hospital. Methods: 395 women underwent
surgical intervention for DCIS between 2000 and 2011. Their race/ethnicity was
divided into five mutually exclusive categories and demographic and
clinicopathological data was collected.
Multivariate analysis was performed to evaluate variations in patient
and tumor factors with respect to age, size
and surgical management among different ethnicities and races. Results: 82.1%
of Caucasian women underwent simple mastectomy with sentinel lymph node biopsy (SLNB)
while lumpectomy with SLNB was highest in Hispanics (40%, p = 0.005). Overall, there was no significant difference in the
incidence of receptor or HER-2/neu