%0 Journal Article %T Risk Factors, Clinical Features, Baseline Alanine Aminotransferase and CD4<sup>+</sup> Count of Children with HIV Co-Infection with Hepatitis B and C at a Tertiary Hospital in Southwest Nigeria %A M. O. Durowaye %A S. K. Ernest %A I. A. Ojuawo %J International Journal of Clinical Medicine %P 280-291 %@ 2158-2882 %D 2016 %I Scientific Research Publishing %R 10.4236/ijcm.2016.74030 %X Background: Human immunodeficiency virus and hepatitis B and C viruses are endemic in sub- Saharan African countries including Nigeria. Researchers have studied the burden of co-infection of HIV with hepatitis B and hepatitis C but the risk factors and clinical presentation have not been much addressed especially in children. Methodology: This was a prospective cross sectional study that determined the prevalence, risk factors, clinical features, baseline CD4+ count, CD4+ percentage, and alanine aminotransferase (ALT) of newly diagnosed, HAART na?ve HIV co-infection among children who were managed at a Tertiary Hospital in Ilorin, Nigeria. Result: Of the 60 HIV- infected children recruited, 11.7% had HIV co-infection with HBV or HCV. Children with co-infec- tions (mean age 8.43 ¡À 2.37 years) were significantly older than their HIV mono-infected counterparts (mean age 5.25 ¡À 3.96 years) (p = 0.011). There was no significant difference between HIV monoinfection and HIV co-infection with respect to gender (p = 0.758), ethnicity (p = 0.707), religion of parents (p = 0.436), family type (p = 0.184), social class (p = 0.535), previous transfusion (p = 0.053), scarification (p = 0.612), female genital mutilation (p = 0.778), and sharing of clippers (p = 0.806). The mean BMI, immunological staging (p = 0.535), baseline ALT (p = 0.940), and mean baseline CD4+ count (p = 0.928) were comparable. However, the body mass index of HIV co-infec- ted children decreased with age up till age 10 years. Conclusion: There were no risk factors, nor clinical features predictive of co-infection identified in this study. Co-infection did not negatively impact baseline, CD4+ count and ALT. %K Co-Infection %K Hepatitis B %K Hepatitis C %K Human Immunodeficiency Virus %K Acquired Immunodeficiency Syndrome %K HIV %K HBV %K HCV %K Alanine Aminotransferase %K ALT %K Highly Active Antiretroviral Therapy %K HAART %K Monoinfection %K CD4+ %K Risk Factors for Co-Infection %K Transmission %K Hepatitis B Surface Antigen %K HBVsAg %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=66115