%0 Journal Article %T PPAR- Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration %A Marisol del V Cano %A Peter L. Gehlbach %J PPAR Research %D 2008 %I Hindawi Publishing Corporation %R 10.1155/2008/821592 %X The peroxisome proliferator-activated receptors (PPAR's) are members of the steroid/thyroid nuclear receptor, superfamily of transcription factors. There are currently three known PPAR subtypes, , , and . The PPARs are now recognized participants in a number of biological pathways some of which are implicated in the pathogenesis of age-related macular degeneration (AMD). These include immune modulation, lipid regulation, and oxidant/antioxidant pathways important to the onset and progression of “dry” AMD, and vascular endothelial growth factor (VEGF) mediated pathways that stimulate choroidal neovascularization (CNV), characteristic of “wet” AMD. PPAR- is found in retina and also on vascular cells important to formation of CNV. At this time, however, relatively little is known about potential contributions of PPAR- to the pathogenesis of dry and wet AMD. This review examines current literature for potential roles of PPAR- in the pathogenesis and potential treatment of AMD with emphasis on prevention and treatment of wet AMD. %U http://www.hindawi.com/journals/ppar/2008/821592/