%0 Journal Article
%T Convergence of Y chromosome STR haplotypes from different SNP haplogroups compromises accuracy of haplogroup prediction
%A Chuan-Chao Wang
%A Ling-Xiang Wang
%A Rukesh Shrestha
%A Shaoqing Wen
%A Manfei Zhang
%A Xinzhu Tong
%A Li Jin
%A Hui Li
%J Quantitative Biology
%D 2013
%I arXiv
%X Short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) are two kinds of commonly used markers in Y chromosome studies of forensic and population genetics. There has been increasing interest in the cost saving strategy by using the STR haplotypes to predict SNP haplogroups. However, the convergence of Y chromosome STR haplotypes from different haplogroups might compromise the accuracy of haplogroup prediction. Here, we compared the worldwide Y chromosome lineages at both haplogroup level and haplotype level to search for the possible haplotype similarities among haplogroups. The similar haplotypes between haplogroups B and I2, C1 and E1b1b1, C2 and E1b1a1, H1 and J, L and O3a2c1, O1a and N, O3a1c and O3a2b, and M1 and O3a2 have been found, and those similarities reduce the accuracy of prediction.
%U http://arxiv.org/abs/1310.5413v1