%0 Journal Article
%T Multiscale Identification of Topological Domains in Chromatin
%A Darya Filippova
%A Rob Patro
%A Geet Duggal
%A Carl Kingsford
%J Quantitative Biology
%D 2013
%I arXiv
%X Recent chromosome conformation capture experiments have led to the discovery of dense, contiguous, megabase-sized topological domains that are similar across cell types and conserved across species. These domains are strongly correlated with a number of chromatin markers and have since been included in a number of analyses. However, functionally-relevant domains may exist at multiple length scales. We introduce a new and efficient algorithm that is able to capture persistent domains across various resolutions by adjusting a single scale parameter. The identified novel domains are substantially different from domains reported previously and are highly enriched for insulating factor CTCF binding and histone modfications at the boundaries.
%U http://arxiv.org/abs/1307.7862v1