%0 Journal Article
%T GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons
%A H. Golan
%A K. Mikenberg
%A V. Greenberger
%A M. Segal
%J Neural Plasticity
%D 2000
%I Hindawi Publishing Corporation
%R 10.1155/np.2000.31
%X Dissociated hippocampal neurons, grown in culture for 2 to 3 weeks, tended to fire bursts of synaptic currents at fairly regular intervals, representing network activity. A brief exposure of cultured neurons to GABA caused a total suppression of the spontaneous network activity. Following a washout of GABA, the activity was no longer clustered in bursts and instead, the cells fired at a high rate tonic manner. The effect of removing GABA could be seen as long as 1 to 2 days after GABA withdrawal and is expressed as an increase in the number of active cells in a network, as well as in their firing rates. Such striking effects of GABA removal may underlie part of the GABA withdrawal syndrome seen elsewhere.
%U http://www.hindawi.com/journals/np/2000/364384/abs/