%0 Journal Article %T Histoplasma Virulence and Host Responses %A Mircea Radu Mihu %A Joshua Daniel Nosanchuk %J International Journal of Microbiology %D 2012 %I Hindawi Publishing Corporation %R 10.1155/2012/268123 %X Histoplasma capsulatum is the most prevalent cause of fungal respiratory disease. The disease extent and outcomes are the result of the complex interaction between the pathogen and a host's immune system. The focus of our paper consists in presenting the current knowledge regarding the multiple facets of the dynamic host-pathogen relationship in the context of the virulence arsenal displayed by the fungus and the innate and adaptive immune responses of the host. %U http://www.hindawi.com/journals/ijmb/2012/268123/