%0 Journal Article
%T Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats
%A Aluet Borrego
%A Zullyt B. Zamora
%A Ricardo Gonz¨˘lez
%A Cheyla Romay
%A Silvia Men¨Śndez
%A Frank Hern¨˘ndez
%A Teresita Montero
%A Enys Rojas
%J Mediators of Inflammation
%D 2004
%I Hindawi Publishing Corporation
%R 10.1080/09629350410001664806
%X Background: Acute renal failure is a dose-limiting factor of cisplatin chemotherapy. Here, we show the protective effect of ozone oxidative preconditioning against cisplatin-induced renal dysfunction in rats. Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant–pro-oxidant balance for preservation of the cell redox state by increasing antioxidant endogenous systems in various in vivo and in vitro experimental models.
%U http://www.hindawi.com/journals/mi/2004/896047/abs/