%0 Journal Article
%T Synthetic Resveratrol Derivatives and Their Biological Activities: A Review
%A Ya Liu
%A Yi Liu
%A Hongfei Chen
%A Xu Yao
%A Yan Xiao
%A Xianliang Zeng
%A Qutong Zheng
%A Yun Wei
%A Chen Song
%A Yinxiang Zhang
%A Peng Zhu
%A Juan Wang
%A Xing Zheng
%J Open Journal of Medicinal Chemistry
%P 97-105
%@ 2164-313X
%D 2015
%I Scientific Research Publishing
%R 10.4236/ojmc.2015.54006
%X Resveratrol, a naturally derived stilbene that exists in various foods and beverages, has attracted extensive exploration due to its multiple biological activities, such as anticancer, antioxidant, cardiovascular protection, anti-inflammatory, antiviral, chemopreventive effect, neuroprotective effect, immunomodulation and so on. However, owing to its poor oral bioavailability, the application of resveratrol is greatly restricted. Because of that, a large amount of efforts had been made by researchers on designing its derivatives to obtain compounds with improved efficiency and low toxicity for developing more active drugs for clinical application. In this report, we review the current development of studying on resveratrol derivatives including their properties and activities. Additionally, this article also presents the synthetic routes of correlative resveratrol derivatives.
%K Anticancer
%K Antioxidant
%K Anti-Inflammatory
%K Resveratrol Derivatives
%K Structure-Activity Relationship (SAR)
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=61784