%0 Journal Article
%T Synthesis of Fluorinated Heterobicyclic Nitrogen Systems Containing 1,2,4-Triazine Moiety as CDK2 Inhibition Agents
%A Mohammed Saleh Tawfik Makki
%A Reda Mohammdy Abdel-Rahman
%A Faisal Mohammed Aqlan
%J International Journal of Organic Chemistry
%P 200-211
%@ 2161-4695
%D 2015
%I Scientific Research Publishing
%R 10.4236/ijoc.2015.53020
%X New fluorine substituted heterobicyclic nitrogen system as imidozolopyrimidines (2,3), pyrimido- 1,2,4-triazinones (4-7), 1,2,4-triazinyl-1,2,4-triazine (12-16), 1,2,4-triazinyl-1,2,4-triazinones (14-17) and substituted thiobarbituric acids (19-20), have been synthesized using the reaction of 3- amino-5,6-di (4'-fluorophenyl)-1,2,4-triazine (1) with <em>¦Á</em>,<em>¦Â</em>¨Cbifunctional compounds. Structures of the title compounds were characterized by UV, IR, <sup>1</sup>H/<sup>13</sup>C-NMR and mass spectrometric method. The studied compounds were tested for CDK2 inhibiting activity in DNA damage, as well as<em> in vitro</em> anti-tumor activity.
%K Synthesis
%K Fluoroheterobicyclic Nitrogen
%K CDK2 Inhibition
%K Anti-Tumor Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=60000