%0 Journal Article
%T The selenium content of SEPP1 versus selenium requirements in vertebrates
%A Sam Penglase
%A Kristin Hamre
%A Stle Ellingsen
%J PeerJ
%D 2015
%I 
%R 10.7287/peerj.preprints.784v1
%X Selenoprotein P (SEPP1) distributes selenium (Se) throughout the body via the circulatory system. The Se content of SEPP1 varies from 7 to 18 Se atoms depending on the species, but the reason for this variation remains unclear. Herein we provide evidence that vertebrate SEPP1 Sec content correlates positively with Se requirements (R2=0.88). As the Se content of full length SEPP1 is genetically determined, this presents a unique case where a nutrient requirement can be predicted based on genomic sequence information.
%K Selenoprotein P
%K Selenium requirements
%K Nutrition
%K SEPP1
%U https://peerj.com/preprints/784/