%0 Journal Article
%T Synthesis of Novel Fluorine Substituted Isolated and Fused Heterobicyclic Nitrogen Systems Bearing 6-(2¡¯-Phosphorylanilido)-1,2,4-Triazin-5-One Moiety as Potential Inhibitor towards HIV-1 Activity
%A Reda M. Abdel-Rahman
%A Mohammed S. T. Makki
%A Abeer N. Al-Romaizan
%J International Journal of Organic Chemistry
%P 247-268
%@ 2161-4695
%D 2014
%I Scientific Research Publishing
%R 10.4236/ijoc.2014.44028
%X Novel 6-(5¡¯-fluoro-2¡¯-diphenylphosphorylanilido)-3-hydrazino-1,2,4-trizin-5 (2H) one (3) is achieved from hydrozinolysis of the corresponding 3-thioxo-analoges 2. Compound 2 is also obtained from phosphorylation of 6-(5¡¯-fluoro-2¡¯-aminophenyl)-3-thioxo-1,2,4-triazin-5(2H) one (1). Novel fluorine substituted isolated and/or fused heterobicyclic nitrogen systems bearing and/or containing, 6-phosphoryl anilido-1,2,4-trizin-5 (2H) one moiety (4 - 22) have been synthesized from ring closure reactions of compound 3 with ¦Ð-acceptors activated carbon compounds in different medium and conditions. Structures of the products are characterized by MS, IR, UV-VIS, CH, N, and 1H/13CNMR spectral data. The new products have been evaluated as potential inhibitors towards HIV-1 activity.
%K Synthesis
%K Fluorine
%K Phosphorus
%K Sulfar 1
%K 2
%K 4-Trizinones HIV-1
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=52328