%0 Journal Article
%T Presence of the Genes <i>cag</i>A, <i>cag</i>E, <i>vir</i>B11 and Allelic Variation of <i>vac</i>A of <i>Helicobacter pylori</i> Are Associated with the Activity of Gastritis
%A Pedro Pinheiro de Negreiros Bessa
%A Francivandi Coelho Barbosa
%A Ana Paula Santos do Carmo
%A Gildo Barreira Furtado
%A Fernanda Capelo Barroso
%A Silvia Helena Barem Rabenhosrt
%J Open Journal of Gastroenterology
%P 347-355
%@ 2163-9469
%D 2014
%I Scientific Research Publishing
%R 10.4236/ojgas.2014.411049
%X Non-atrophic active
chronic gastritis (ACG) is characterized by the presence of <i>H. pylori</i> in the gastric epithelium,
known to be one of the first steps that precede progression to gastric
adenocarcinoma. Inactive chronic gastritis (<span>ICG) suggests that the patient has <i>H. pylori</i> gastritis, but this
diagnosis is rarely made in routine histopathology. C</span>linical
manifestations associated with <i>H. pylori </i>infection are potentially due
to differences in virulence between strains; however, it is unclear if the
progression of ACG to ICG depends on the <i>H.
pylori</i> strain. The aim of this study was to compare the prevalence of the
virulence factors of <i>H. pylori </i>found
in patients with ACG and ICG, and its influence on the development of ICG. A
significant association was observed between <i>H. pylori </i>detection by histological examination and the activity of
gastritis (p &lt; 0.01). Long-term use of proton pump inhibitors (PPI) (&gt;1
year) was reported by 28.6% of the ACG group and 42.5% of the ICG, while no
evidence of association between long-term use of PPI and decreased inflammation
was found in the patients studied. The genes <i>cag</i>A, <i>cag</i>E and <i>vir</i>B11 were statistically associated with
ACG (p = 0.01, p &lt; 0.001 and p = 0.002, respectively). In the <i>vac</i>As1 allele groups, ACG was associated
with the most virulent group (p = 0.0015), while ICG was associated with the
less virulent group (p &lt; 0.001). The rate of co-infection was significantly
higher in ICG than in ACG cases (p = 0.02). In conclusion, this study points to
the role of virulent strains of <i>H. pylori</i> in the non-resolution of gastritis.
%K Active Chronic Gastritis
%K Inactive Chronic Gastritis
%K &lt
%K i&gt
%K Helicobacter pylori&lt
%K /i&gt
%K Genotypes
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=51648