%0 Journal Article
%T 蛋白去乙酰基酶SIRT1的免疫调节效应及机制<br>Immunomodulation and Mechanism of Protein Deacetylase SIRT1
%A 张妍
%A 张正国
%A 汉丽梅
%A 刘光伟
%J Immunology Studies
%P 7-10
%@ 2330-1678
%D 2013
%I Hans Publishing
%R 10.12677/IS.2013.12002
%X <p>
	<div style=\"text-align:justify;\">
		<span style=\"line-height:1.5;\">机体免疫分为</span><span style=\"line-height:1.5;\">天然免疫和适应性免疫，分别由不同的免疫细胞介导。</span><span style=\"line-height:1.5;\">SIRT1</span><span style=\"line-height:1.5;\"> (</span><span style=\"line-height:1.5;\">silent mating
type information regulation 2 homolog 1</span><span style=\"line-height:1.5;\">)</span><span style=\"line-height:1.5;\">是一种具有烟酰胺腺嘌呤二核苷酸</span><span style=\"line-height:1.5;\">(</span><span style=\"line-height:1.5;\">Nicotinamide Adenine Dinucleotide</span><span style=\"line-height:1.5;\">, </span><span style=\"line-height:1.5;\">NAD</span><span style=\"line-height:1.5;\">)</span><span style=\"line-height:1.5;\">依赖性的蛋白去乙酰基酶活性的转录调节因子，在细胞寿命和机体代谢中发挥重要作用。近年来，</span><span style=\"line-height:1.5;\">SIRT1</span><span style=\"line-height:1.5;\">在免疫中的调控作用逐渐为研究者所重视。本文仅就</span><span style=\"line-height:1.5;\">SIRT1</span><span style=\"line-height:1.5;\">在天然免疫和适应性免疫中的调控效应及分子机制做一简要综述。</span>
	</div>
	<div style=\"text-align:justify;\">
		<span style=\"line-height:1.5;\">Different kinds of lymphocytes could be
involved in the innate immunity and adaptive immunity. Silent mating type
information regulation 2 homolog 1 (SIRT1) is a Nicotinamide Adenine
Dinucleotide (NAD)-dependent protein deacetylase, which plays a critical role
in life span and metabolism. Recently, the immune functional studies of SIRT1
have become a hot spot in immunological field. This review only summarizes the
modulation of SIRT1 on both innate immunity and adaptive immunity and its
molecular mechanism.</span>
	</div>
</p>
%K SIRT1；巨噬细胞；T细胞；免疫调节<br>SIRT1
%K Macrophages
%K T Cells
%K Immune Modulation
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=12577