%0 Journal Article
%T Pea3 transcription factor promotes neurite outgrowth
%A BASAK KANDEMIR
%A BERRAK CAGLAYAN
%A BARBARA HAUSOTT
%A UGUR DAG
%A OZLEM DEMIR
%A MELIS SAVASAN SOGUT
%A Lars Klimaschewski
%A ISIL AKSAN KURNAZ
%J Frontiers in Molecular Neuroscience
%D 2014
%I Frontiers Media
%R 10.3389/fnmol.2014.00059
%X Pea3 subfamily of ETS transcription factors consist of three major proteins, Pea3, ERM and ER81. Although important for many different tissues that exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this study, we provide evidence that Pea3 can directs neurite extension and axonal outgrowth in different model systems, and that Serine 90 is important for this function. We have also identified neurofilament-L and neurofilament-M as two putative novel targets for Pea3.
%K Pea3
%K Neuron
%K axonal outgrowth
%K Phosphorylation
%K neurofilaments
%U http://www.frontiersin.org/Journal/10.3389/fnmol.2014.00059/abstract