%0 Journal Article
%T Upstream deregulation of calcium signaling in Parkinson¡¯s disease
%A Pilar Rivero-R¨ªos
%A Patricia G¨®mez-Suaga
%A Elena Fdez
%A Sabine Hilfiker
%J Frontiers in Molecular Neuroscience
%D 2014
%I Frontiers Media
%R 10.3389/fnmol.2014.00053
%X Parkinson¡¯s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca2+ stress which may determine their selective vulnerability, and suggest how abnormal Ca2+ handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental, and genetic stress. Gaining a better understanding of the varied effects of Ca2+ dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression.
%K Parkinson¡¯s disease
%K dopamine
%K calcium
%K mitochondria
%K endoplasmic reticulum
%K lysosomes
%K Golgi
%U http://www.frontiersin.org/Journal/10.3389/fnmol.2014.00053/abstract