%0 Journal Article
%T Differential transforming activity of the retroviral Tax oncoproteins in human T lymphocytes
%A Tong Ren
%A Hua Cheng
%J Frontiers in Microbiology
%D 2013
%I Frontiers Media
%R 10.3389/fmicb.2013.00287
%X Human T cell leukemia virus type 1 and type 2 (HTLV-1 and -2) are two closely related retroviruses. HTLV-1 causes adult T cell leukemia and lymphoma, whereas HTLV-2 infection is not etiologically linked to human disease. The viral genomes of HTLV-1 and -2 encode highly homologous transforming proteins, Tax-1 and Tax-2, respectively. Tax-1 is thought to play a central role in transforming CD4+ T lymphocytes. Expression of Tax-1 is crucial for promoting survival and proliferation of virally infected human T lymphocytes and is necessary for initiating HTLV-1-mediated oncogenesis. In transgenic mice and humanized mouse model, Tax-1 has proven to be leukemogenic. Although Tax-1 is able to efficiently transform rodent fibroblasts and to induce lymphoma in mouse model, it rarely transforms primary human CD4+ T lymphocytes. In contrast, Tax-2 efficiently immortalizes human CD4+ T cells though it exhibits a lower transforming activity in rodent cells as compared to Tax-1. We here discuss our recent observation and views on the differential transforming activity of Tax-1 and Tax-2 in human T cells.
%K HTLV-1/-2
%K Tax
%K human T lymphocytes
%K immortalization
%K transformation
%U http://www.frontiersin.org/Journal/10.3389/fmicb.2013.00287/abstract