%0 Journal Article
%T Elevated Plasma Levels but Decreased Platelet-Associated Expression of LIGHT in Patients with Acute Atherothrombotic Stroke
%A Guangzhi Liu
%A Yang He
%A Tingting Yang
%A Hong Jiang
%A Yajuan Xiang
%A Qi Zhang
%A Xiangjun He
%A Peter Hjelmstrom
%A Xuguang Gao
%J World Journal of Neuroscience
%P 385-393
%@ 2162-2019
%D 2014
%I Scientific Research Publishing
%R 10.4236/wjns.2014.44042
%X Background: As a member of the tumor necrosis factor superfamily (TNFSF), LIGHT (TNFSF14) is expressed by a variety of immune cells
and exists in membrane-bound and soluble forms. Recently, LIGHT was found to be
associated with platelets and released upon activation. Activation of endothelia
cells by recombinant LIGHT protein results in pro-inflammatory and
pro-thrombotic changes. Several studies have reported increased plasma levels
of LIGHT in patients with stroke and cardiovascular diseases. However, the
form-associated roles of LIGHT in ischemic atherosclerotic stroke remain unclear. Mater?als and Methods: In this study, the
platelet LIGHT expression and soluble LIGHT protein were analyzed by flow
cytometry and enzyme-linked immunosorbent assay (ELISA) in peripheral blood of
patients with acute ischemic atherosclerotic stroke, asymptomatic carotid
stenosis (ACS) and normal controls. RESULTS: During the initial 24 h
after onset, the stroke patients had decreased LIGHT expression on their
platelets (5.9% ¡À 4.9%) and increased plasma LIGHT levels (36.1 ¡À 21.0 pg/ml) as compared with normal
controls (9.5% ¡À 3.0%, p < 0.05; 20.4 ¡À 13.4 pg/ml, p < 0.05).
Moreover, the platelet LIGHT expression correlated with total plaque area in
the stroke patients (r = 0.4572, p = 0.0247). Conclus?ons: The dysregulated LIGHT
expression reflects a persistent chronic inflammatory
%K LIGHT
%K Ischemic Atherosclerotic Stroke
%K Atherogenesis
%K Peripheral Blood
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=48904