%0 Journal Article
%T Uptake of Bile Acid into Calcium-Induced  Alginate Gel Beads Containing <i>¦Â</i>-Chitosan Weak Acid Salt
%A Yoshifumi Murata
%A Kyoko Kofuji
%A Norihisa Nishida
%A Ryosei Kamaguchi
%J Pharmacology & Pharmacy
%P 349-355
%@ 2157-9431
%D 2014
%I Scientific Research Publishing
%R 10.4236/pp.2014.54042
%X <p style=\"text-align:justify;\">
	<span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">Recently,
potential applications for </span><i><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">¦Â</span></i><span style=\"font-size:10.0pt;line-height:97%;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;line-height:1.5;\">-chitosan (</span><i><span style=\"font-family:Verdana;line-height:1.5;\">¦Â</span></i><span style=\"font-family:Verdana;line-height:1.5;\">-CS)
have been examined. In the present study, calcium-induced alginate gel beads
(Alg-Ca) containing weak acid salts of </span><i><span style=\"font-family:Verdana;line-height:1.5;\">¦Â</span></i><span style=\"font-family:Verdana;line-height:1.5;\">-CS
were prepared and examined with regard to their ability to adsorb bile acids </span><i><span style=\"font-family:Verdana;line-height:1.5;\">in
vitro</span></i><span style=\"font-family:Verdana;line-height:1.5;\">. More than 70% of taurocholate dissolved in solution was taken up by
Alg-Ca containing 100 mg </span><i><span style=\"font-family:Verdana;line-height:1.5;\">¦Â</span></i><span style=\"font-family:Verdana;line-height:1.5;\">-CS, sim. ilar
to the degree of uptake observed with Alg-Ca containing </span></span><i><span style=\"font-size:10pt;line-height:1.5;font-family:Verdana;\">¦Á</span></i><span style=\"font-size:10.0pt;line-height:97%;font-family:;\" \"=\"\"><span style=\"font-family:Verdana;line-height:1.5;\">-CS salt. The adsorption of bile acid was affected
by the absolute amount of </span><i><span style=\"font-family:Verdana;line-height:1.5;\">¦Â</span></i><span style=\"font-family:Verdana;line-height:1.5;\">-CS and/or
the acid concentration of the preparation. A secondary bile acid,
taurodeoxycholate, was also adsorbed by Alg-Ca containing weak acid salts of </span><i><span style=\"font-family:Verdana;line-height:1.5;\">¦Â</span></i><span style=\"font-family:Verdana;line-height:1.5;\">-CS. Therefore, </span><i><span style=\"font-family:Verdana;line-height:1.5;\">¦Â</span></i><span style=\"font-family:Verdana;line-height:1.5;\">-CS might be used to adsorb bile acids within the gastrointestinal
tract in the same manner as an anion-exchange resin, and thus serve as a
complementary means by which to prevent hyperlipidemia.</span></span> 
</p>
%K &lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K -Chitosan
%K Bile Acid Adsorption
%K Alginate Gel Bead
%K Hyperlipidemia
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44654