%0 Journal Article
%T Skin-Sparing Mastectomy and Breast  Reconstruction: An Update for Clinical  Practice
%A Abdul Kasem
%A Christina Choy
%A Kefah Mokbel
%J Journal of Cancer Therapy
%P 264-280
%@ 2151-1942
%D 2014
%I Scientific Research Publishing
%R 10.4236/jct.2014.53034
%X <p class=\"MsoNormal\">
	<span style=\"font-size:10pt;font-family:'}', serif;\" lang=\"EN-US\"><span style=\"font-size:12px;font-family:Verdana;\">Aim: To provide an
up-to-date review of the literature on skin-sparing mastectomy (SSM) for breast
cancer (BC). The article also reviews the oncological safety, effects of
radiotherapy (RT) on immediate breast reconstruction (IBR), the indications for
preserving the nipple-areola complex (NAC) and the emerging role of allogenic
grafts as adjuncts to implant in IBR. Methods: Review of the English literature
from 1965 to 2013</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">was carried out
using Medline and PubMed research engines. Results:</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">SSM is oncologically</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">safe in appropriately selected cases
of invasive breast cancer (IBC) and ductal carcinoma</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"><i> </i></span><i><span style=\"font-size:12px;font-family:Verdana;\">in-situ</span></i><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">(DCIS) including IBC &lt;</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">5</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">cm,
multi-centric tumours, DCIS and for risk-reduction surgery. Inflammatory breast
cancer and tumours with extensive skin involvement represent contra-indications
to SSM due to an unacceptable risk of local recurrence. Prior breast
irradiation or the need for post-mastectomy radiotherapy (PMRT) do not preclude
SSM with IBR, however the aesthetic outcome may be compromised by radiation.
Preservation of the nipple-areola complex (NAC)</span><span class=\"apple-converted-space\" style=\"font-size:12px;font-family:Verdana;\"> </span><span style=\"font-size:12px;font-family:Verdana;\">has aesthetic and psychological
benefits and is safe for peripherally located node negative unifocal</span><span class=\"apple-converted-space\"
%K Skin-Sparing Mastectomy
%K Breast Reconstruction
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=44114