%0 Journal Article
%T A Comparative Physiochemical Properties of Esomeprazole Brands
%A Safila Naveed
%A Fatima Qamar
%J Open Access Library Journal
%V 1
%N 6
%P 1-5
%@ 2333-9721
%D 2014
%I Open Access Library
%R 10.4236/oalib.1100614
%X Esomeprazole is the S-isomer of Omeprazole and it is
a proton pump inhibitor (PPI). Esomeprazole is used in acid-related disorders
and it is available as several brands in the market which makes it difficult
for doctors to select the effective, safe and economic one for patients.
Therefore we have decided to establish pharmaceutical equivalence among the
different brands of esomeprazole available in Karachi, Pakistan. In our present
study different brands of esomeprazole are evaluated for weight variation,
hardness and dissolution. Disintegration Test shows results for NEX 01, ESS 02,
EZI 03 and they disintegrate in 1.35, 1.15 and 2.15 minutes respectively. Dissolution
test demonstrate the result as NEX 01, ESS 02, EZI 03 is 100.00% for NEX,
117.87% for ESS and 80.66%. The results showed that all parameters
weight-variation, hardness, dissolution of different brands of esomeprazole are
in accordance with the USP limits.
%K Esomeprazole
%K Thickness
%K Weight Variation
%K Hardness
%K Friability
%U http://www.oalib.com/paper/3065216